ea0086p225 | Metabolism, Obesity and Diabetes | SFEBES2022
Clavelo-Farrow C
, Leslie KA
, Fletcher M
, Docherty FM
, Akerman I
, Gallagher MT
, Thomas P
Background: It is widely believed that increased circulatory concentrations of long-chain saturated fatty acids (LC-SFA) significantly contribute to the death and dysfunction of pancreatic β-cells in the development of type 2 diabetes (T2D). The mechanism by which LC-SFA cross the β-cell plasma membrane has not been fully established. This work aims to characterise the mechanism underpinning this uptake. Ultimately, regulation of LC-SFA entry may maintain β-cell...